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What is the mechanism of action of chloroquine? The major action of chloroquine is to inhibit the formation of hemozoin (Hz) from the heme released by the digestion of hemoglobin (Hb). The free heme then lyses membranes and leads to parasite death. Chloroquine resistance is due to a decreased accumulation of chloroquine in the food vacuole.
Is mefloquine available in India? I don't recommend Mefloquine but it is available in Delhi at places. Malarone is not available in India.
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