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Is there a substitute for methotrexate? Leflunomide is also an effective DMARD. Its efficacy is similar to methotrexate in terms of signs and symptoms, and is a viable alternative to patients who have failed or are intolerant to methotrexate.
Should methotrexate be taken with food? Do not take more or less medicine than ordered. This medicine can be taken with or without food. You should also take 1mg of folate (folic acid) each day.
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