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Can Prograf be crushed? Do not open, cut, crush, or chew the capsule. Prograf should not be confused with Advagraf brand of tacrolimus. They cannot be interchanged. If your medication looks different than what you have been taking, talk to your pharmacist or transplant doctor.
What are side effects of Prograf? Side Effects. Shaking, headache, diarrhea, nausea / vomiting, upset stomach, loss of appetite, trouble sleeping, and tingling of the hands/feet may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.